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Publications

  • Mochi JA, Jani J, Shah S, Pappachan A. Leishmania donovani adenylosuccinate synthetase requires IMP for dimerization and organization of the active site. FEBS Lett. 2024 Oct 27. doi: 10.1002/1873-3468.15040. Epub ahead of print. PMID: 39462612.
  • Mochi JA, Jani J, Tak K, Pappachan A. Insights into the ATP / GTP selectivity of a GTPase, adenylosuccinate synthetase from Leishmania donovani. Biochem Biophys Res Commun. 2024 Jun 30;715:149975. doi: 10.1016/j.bbrc.2024.149975. Epub 2024 Apr 23. PMID: 38676997.
  • Mochi JA, Jani J, Tak K, Lodhi KK, Pananghat G, Pappachan A. Arg40 is critical for stability and activity of Adenylosuccinate lyase; a purine salvage enzyme from Leishmania donovani. Arch Biochem Biophys. 2024 Jul;757:110040. doi: 10.1016/j.abb.2024.110040. Epub 2024 May 13. PMID: 38750922.
  • Vijayasurya, Gupta S, Shah S, Pappachan A. Drug repurposing for parasitic protozoan diseases. Prog Mol Biol Transl Sci. 2024;207:23-58. doi: 10.1016/bs.pmbts.2024.05.001. Epub 2024 May 16. PMID: 38942539.
  • Gupta S, Jani J, Vijayasurya, Mochi J, Tabasum S, Sabarwal A, Pappachan A. Aminoacyl-tRNA synthetase - a molecular multitasker. FASEB J. 2023 Nov;37(11):e23219.
  • Solanki R; Saini M; Mochi J; Pappachan A; Patel S. Synthesis, characterization, in-silico and in-vitro anticancer studies of Plumbagin encapsulated albumin nanoparticles for breast cancer treatment. Journal of Drug Delivery Science and Technology. 2023; 84: 104501
  • Mochi J, Jani J, Joshi S, Pappachan A, CRISPR-Cas9: chronology and evolution. Editor(s): Swati Joshi, Digvijay Verma, Ravi Kr. Gupta, CRISPR-Cas System in Translational Biotechnology, Academic Press, 2024, Pages 3-21, ISBN 9780323918084
  • Gupta S, Pappachan A, Approaches and tools of protein tailoring for metabolic engineering, Editor(s): Swati Joshi, Ashok Pandey, Ranjna Sirohi, Sung Hoon Park, Current Developments in Biotechnology and Bioengineering, Elsevier, 2022, Pages 131-150, ISBN 9780323885041.
  • Jani J, Pappachan A. A review on quality control agents of protein translation - The role of Trans-editing proteins. Int J Biol Macromol. 2022 Feb 28;199:252-263. doi: 10.1016/j.ijbiomac.2021.12.176. Epub 2022 Jan 4. PMID: 34995670.
  • Bhardwaj G, Vakani M, Srivastava A, Patel D, Pappachan A, Murumkar P, Shah H, Shah R, Gupta S. Swertisin, a novel SGLT2 inhibitor, with improved glucose homeostasis for effective diabetes therapy. Arch Biochem Biophys. 2021 Oct 15;710:108995. doi: 10.1016/j.abb.2021.108995. Epub 2021 Jul 18. PMID: 34289381.
  • Patel B, Patel D, Pappachan A. Ile209 of Leishmania donovani xanthine phosphoribosyltransferase plays a key role in determining its purine base specificity. FEBS Lett. 2021 Aug;595(16):2169-2182. doi: 10.1002/1873-3468.14162. Epub 2021 Jul 26. PMID: 34268726.
  • Jani, J.,Pappachan, A. (2021). Protein Analysis: From Sequence to Structure. In: Singh, V., Kumar, A. (eds) Advances in Bioinformatics. Springer, Singapore. https:doi.org/10.1007/978-981-33-6191-1_4
  • Kulkarni PG, Shah N, Waghela BN, Pathak CM, Pappachan A Leishmania donovani adenylate kinase 2a prevents ATP-mediated cell cytolysis in macrophages. Parasitol Int. 2019 May 17;72:101929. doi: 10.1016/j.parint.2019.101929. [Epub ahead of print]
  • Patel B, Patel D, Parmar K, Chauhan R, Singh DD, Pappachan A. L. donovani XPRT: Molecular characterization and evaluation of inhibitors. Biochim Biophys Acta- Proteins and Proteomics. 2018 Mar,1866(3), 426-441
  • Kumar M, Ranjan K, Singh V, Pathak C, Pappachan A, Singh DD. Hydrophilic Acylated Surface Protein A (HASPA) of Leishmania donovani: Expression, Purification and Biophysico-Chemical characterization. 2017 Protein J 36: 343–351
  • Patel DK., Shah KR., Pappachan A, Gupta S, Singh DD. Cloning, expression and characterization of a mucin binding GAPDH from Lactobacillus acidophilus. 2016 Int J Biol Macromol. 91: 338-346
  • Shah KR., Patel DK., Pappachan A, Ratna Prabha C, Singh DD. Characterization of a Kunitz-type serine protease inhibitor from Solanum tuberosum having lectin activity. 2016 Int J Biol Macromol. 83: 259-269
  • Singh V, Nair DN., Kaushal RS, Kumar M, Pappachan A, Singh DD. Heterologous expression, purification and characterization of L-type lectin homologue from Leishmania donovani. Biotechnology Reports. 2015 8:81-87
  • Yamuna Kalyani M, Pappachan A, Savithri HS, Murthy MR. Investigations on the role of domain swapping in the symmetry, structure and function of a Stationary Phase Survival Protein (SurE) from Salmonella typhimurium. PLoS One. 2013 8(2):e55978
  • Xavier JR, Gnanam R, Murugan MP, Pappachan A. Clonal propagation of Phyllanthus amarus: A hepatoprotector. Phcog Mag. 2012;8:78-82.
  • Pappachan A, Subashchandrabose C, Satheshkumar PS, Savithri HS, Murthy MR. A single point mutation disrupts the capsid assembly in Sesbania Mosaic Virus resulting in a stable isolated dimer. Virology. 2009 Sep 30:392(2):215-21 (cover page article).
  • Pappachan A, Savithri HS, Murthy MR. Structural and functional studies on a mesophilic stationary phase survival protein (Sur E) from Salmonella typhimurium. FEBS J. 2008 Dec;275(23):5855-64.
  • Pappachan A, Subashchandrabose C, Satheshkumar PS, Savithri HS, Murthy MR. Structure of recombinant capsids formed by the β-annulus deletion mutant - rCP (∆48-59) of Sesbania Mosaic Virus. Virology. 2008 May 25;375(1):190-6. (cover page article)